I'm not a big "fan" of OTC (Over the Counter) medication as I look for "alternative" natural remedies first. Instead of "pain-killers" (e.g. Advil, Tyenol, etc...->too many "side-effects"), I take this.

WARNING: It taste "grouse", but I quickly drink or eat something quickly to cover the taste ;)

It really has worked for me, which I used it a lot when I was working on my "metal-roof" project (e.g. carrying "roof shingles" by hand to the dumpster) last summer "quickly" (before the next rain storm).

People not aware of harmful effects of painkillers, study
Saturday 26 November 2005 - 12am PST
there is an increased risk of gastrointestinal complications ranging from stomach pain to ulcers, hemorrhage, and severe and potentially deadly gastrointestinal problems. Each year, the side effects of long-term NSAID use cause nearly 103,000 hospitalizations and 16,500 deaths by some estimates.

Painkillers, ibuprofen - Side effects

Pain Medications
increasing the dose of an opioid may achieve relief, but it can also increase the likelihood of side effects, some of which are dangerous..
...A newer class of anti-inflammatories, the Cox-2 inhibitors, was developed to reduce this risk. It did not, though, eliminate it. In fact, another major issue emerged with these drugs: the possibility of severe and deadly vascular problems with long-term use, including heart attack and stroke. ...
Most users of acetaminophen experience few, if any, side effects. But the drug can cause liver damage, especially when taking too much or if taken with alcohol....

"...Be sure you get enough calcium. Nighttime cramps are often associated with a lack of calcium in the diet. Eat plenty of calcium-rich foods like broccoli, spinach, and dairy products (opt for low-fat or fat-free varieties if you're trying to limit your fat or calorie intake). If cramping is still a problem, talk to your doctor about using a calcium supplement....
Home Remedies From the Fruit Basket

Banana. Eat a banana or two a day, and you may cut down your cramping. That's because a potassium deficiency may be to blame for muscle cramps. Though there's no official recommendation for how much potassium you should have per day, the American Dietetic Association suggests adults get about 2,000 mg a day. One banana has 450 mg of the muscle-protecting nutrient...."

Good News Medical